Flavonoid glycosides and free radical scavenging activity of Bulgarian endemic Alchemilla jumrukczalica Pawl

نویسندگان

  • A. Trendafilova
  • M. Todorova
  • A. Vitkova
  • Bogdan Kurtev
چکیده

The aim of this study was to identify the flavonoid constituents of the Bulgarian endemic Alchemilla jumrukczalica Pawl. and evaluate the antiradical scavenging activity of the total extract, fractions and individual compounds. The total MeOH extract exhibited a significant DPPH activity (IC50 10.7±0.4 μg/ml), while EtOAc fraction obtained after partition of the total extract was found to be the most active radical scavenger (IC50 5.1±0.1 μg/ml). Catechin and seven flavonoid glycosides (guajaverin, hyperoside, isoquercitin, quercitrin, miquelianin, tiliroside and trifolin) were isolated from EtOAc fraction.Their structures were elucidated on the basis of spectral data. Quercetin glycosides (guajaverin, hyperoside and miquelianin) were found to be better DPPH radical scavengers than kaempferol-3-O-galactoside and catechin.

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تاریخ انتشار 2017